Product Description
Vitamin B1 Hcl/Thiamine Hcl is a water-soluble vitamin that is added to feed formulations. It plays a very important role in energy metabolism and in general health since it triggers the carbohydrate breakdown for energy production. It is odorless, with a neutral taste; it is mostly used without influencing the flavor of the final product. It remains stable during storage provided that it has a shelf life of two years. Vitamin B1 Hcl/Thiamine Hcl is used primarily in the feed industry for enhancing livestock well-being. Easy solubility in water ensures to be perfectly incorporated into various feed types which undoubtedly contributes towards better nutrient absorption and improved performance in animals.
Thiamine plays a very important coenzymatic and non-coenzymatic role in the regulation of basic metabolism. Thiamine diphosphate is a coenzyme of many enzymes, most of which occur in prokaryotes. Pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes as well as transketolase are the examples of thiamine-dependent enzymes present in eukaryotes, including human. Therefore, thiamine is considered as drug or diet supplement which can support the treatment of many pathologies including neurodegenerative and vascular system diseases. On the other hand, thiamine antivitamins, which can interact with thiamine-dependent enzymes impeding their native functions, thiamine transport into the cells or a thiamine diphosphate synthesis, are good propose to drug design. The development of organic chemistry in the last century allowed the synthesis of various thiamine antimetabolites such as amprolium, pyrithiamine, oxythiamine, or 3-deazathiamine. Results of biochemical and theoretical chemistry research show that affinity to thiamine diphosphate-dependent enzymes of these synthetic molecules exceeds the affinity of native coenzyme. Therefore, some of them have already been used in the treatment of coccidiosis (amprolium), other are extensively studied as cytostatics in the treatment of cancer or fungal infections (oxythiamine and pyrithiamine). This review summarizes the current knowledge concerning the synthesis and mechanisms of action of selected thiamine antivitamins and indicates the potential of their practical use.